Epigenomic landscape and 3D genome structure in pediatric high-grade glioma
نویسندگان
چکیده
منابع مشابه
RapidArc: Initial experience in high grade glioma
Background: Identify the optimal technique of radiotherapy for patients with high grade glioma. Our initial year of experience with RapidArc radiation therapy. Materials and Methods: Planning CT scans of 50 patients with grade IV glioma were reviewed and three plan sets by 3D Conformal Radiotherapy (3DCRT), Intensity Modulated Radiotherapy (IMRT) and Rapid Arc (RA) were generated and the plans ...
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Pediatric central nervous system tumors are the most common solid tumor of childhood. Of these, approximately one-third are gliomas that exhibit diverse biological behaviors in the unique context of the developing nervous system. Although low-grade gliomas predominate and have favorable outcomes, up to 20% of pediatric gliomas are high-grade. These tumors are a major contributor to cancer-relat...
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Pediatric high-grade glioma (HGG, WHO Grade III and IV) is a devastating brain tumor with a median survival of less than two years. PDGFRA is frequently mutated/ amplified in pediatric HGG, but the significance of this finding has not been fully characterized. We hypothesize that alterations of PDGFRA will promote distinct prognostic and treatment implications in pediatric HGG. In order to char...
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INTRODUCTION Pediatric high-grade gliomas are rare tumors with poor outcomes and incompletely defined management. We conducted a multi-institutional retrospective study to evaluate association of clinical, pathologic, and treatment characteristics with outcomes. MATERIALS AND METHODS Fifty-one patients treated from 1984 to 2008 at the Ohio State University or University of Michigan were inclu...
متن کاملrapidarc: initial experience in high grade glioma
background: identify the optimal technique of radiotherapy for patients with high grade glioma. our initial year of experience with rapidarc radiation therapy. materials and methods: planning ct scans of 50 patients with grade iv glioma were reviewed and three plan sets by 3d conformal radiotherapy (3dcrt), intensity modulated radiotherapy (imrt) and rapid arc (ra) were generated and the plans ...
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ژورنال
عنوان ژورنال: Science Advances
سال: 2021
ISSN: 2375-2548
DOI: 10.1126/sciadv.abg4126